Rheumatic Manifestations of Endocrine Diseases

Joseph A. Markenson


Curr Opin Rheumatol. 2010;22(1):64-71. 

In This Article

Abstract and Introduction


Purpose of review Musculoskeletal complaints accompanying or as a result of endocrine disorders are common and have been well described. This review re-examines these associations in light of newer information on biology and genetics.
Recent findings In this article, we describe the recent studies on pathophysiology of the muscular skeletal complaints in endocrine disease. In addition we report on population as well as genetic studies, which address the relationship between endocrine and rheumatologic disease, both of which are autoimmune.
Summary Very often, the presentation of rheumatic manifestations is the initial presentation of endocrine disease. Being aware of the presentation as well as the unique physiology of these complaints will help alert the clinician to an early diagnosis of endocrine disease. In addition understanding whether certain endocrine disease occurs more often in rheumatologic illness will enable the clinician to investigate their occurrence early, leading to earlier intervention and resulting in decreased morbidity from these concomitant illnesses.


Rheumatic manifestations may often be the initial presentation of systemic illness. Each endocrine disorder may also have its own arthritic complaints which can present as a definitive rheumatic disease such as calcium pyrophosphate dihydrate deposition (CPPD) or as rheumatic symptoms such as diffuse arthralgia. The rheumatologist as well as the primary care physician should be knowledgeable about the ways in which muscles, tendons ligaments and joints are affected by diseases of the endocrine system. This article will discuss what is new about these manifestations, as well as the therapeutic options available to treat them.


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