Effects of Niacin on LDL Particle Number

Haseeb Jafri; Richard H Karas; Jeffrey T Kuvin


Clin Lipidology. 2009;4(5):565-571. 

In This Article

Niacin Therapy: Data from Clinical Trials

Several clinical trials support that niacin can improve certain defined cardiovascular end points. Theses studies include the Coronary Drug Project, the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), the Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2 and ARBITER 3. The key features of each are listed in Table 1.[19–23] In each of these studies, niacin therapy favorably altered the standard lipid profile, primarily by increasing HDL-C, and may have favorably affected these outcomes via the other mechanisms outlined above. We will now consider whether these improvements in outcomes may also be related to niacin's effect on circulating numbers of LDL-Ps.


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