Use of Antidepressants for Management of Hot Flashes

Dana G. Carroll, Pharm.D.; Kristi W. Kelley, Pharm.D.


Pharmacotherapy. 2009;29(11):1357-1374. 

In This Article


Evidence indicates that antidepressants may be effective in the relief of hot flashes in both breast cancer survivors and healthy menopausal women. Based on the evidence, paroxetine and venlafaxine appear to be the most effective antidepressants in reducing the frequency and severity of hot flashes. Other antidepressants that have been studied may be recommended as second- or third-line options when patients are unable to tolerate paroxetine or venlafaxine. Other agents that have been studied for relief of hot flashes may provide comparable reduction in the frequency and severity of hot flashes. The choice of whether to use an antidepressant or another agent for hot flash relief will be patientspecific, taking into account the patient's other disease states and concomitant drug therapy.


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