Autoimmune Pancreatitis: An Update

Aravind Sugumar; Suresh Chari

Disclosures

Expert Rev Gastroenterol Hepatol. 2009;3(2):197-204. 

In This Article

Pathogenesis

The etiology of AIP is still unknown but there is strong circumstantial evidence suggesting that this may be an autoimmune condition. There is evidence suggesting the HLA DRB1*0405-DQB1*0401 may be associated with AIP observed in Japan when compared with normal and with chronic pancreatitis controls.[34] Numerous autoantibodies, including ones against carbonic anhydrase, antinuclear antibody, rheumatoid factor and lactoferrin, have also been described in conjunction with AIP.[4,5,35,36,37] However, none of these autoantibodies have been show to be exclusive to AIP. In 1990, Hamano et al. showed that there was an association between serum IgG4 levels and AIP.[5] The fact that AIP responds rapidly to steroids suggests an autoimmune etiology. The various theories of the pathogenesis of AIP are beyond the scope of this article and have recently been discussed in other reviews.[28,35,38]

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....