Antibiotics and Probiotics in Inflammatory Bowel Disease: Why, When, and How

Cosimo Prantera; Maria Lia Scribano


Curr Opin Gastroenterol. 2009;25(4):329-333. 

In This Article

NOD2/CARD15 and Resistance to Antibiotics

One important question concerning antibiotics and Crohn's disease is their ineffectiveness in about 40–50% of patients. An interesting light on this problem has been shed by a study on the relationship between antibiotic response and NOD2/CARD15 gene variants. Cipro was dispensed to 49 and metro to 3 patients with perianal disease.[23•] A complete fistula response was recorded in 33.3% of patients with NOD2/CARD15 wild type compared with none of those with NOD2/CARD15 variants. This result could indicate that more than one reason is at the origin of the failure of antibiotics, apart from the bacteria resistance and low patient compliance. Unfortunately, neither Bacteroides nor Enterobacteriaceae group was permanently suppressed by metro-cipro therapy and they tended to reappear when the treatment was stopped.[24•]


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