In conclusion, hypertension and diabetes mellitus are associated with stage 3 or 4 CKD and albuminuria across the full adult age range. Importantly, this association was statistically significantly stronger at younger age groupings. The low overall prevalence of stage 3 or 4 CKD among adults <50 years of age may mask the increased risk of CKD among individuals with hypertension or diabetes mellitus. Further research is needed to better define the differential impact of risk factors for the development of stage 3 or 4 CKD and albuminuria by age group. Additionally, studies aimed at the identification of novel risk factors for stage 3 or 4 CKD and albuminuria, especially among older adults, are warranted.
The authors declare that they have no competing interests.
TMI assisted with the conduct of the statistical analysis and conducted the initial drafting of, and revisions to, the manuscript. CSF participated in the conception of study hypothesis, review of statistical analyses, and provided critical review of the manuscript. DM provided a review of statistical analyses and a critical review of the manuscript. PM participated in the conception of the study hypothesis, conducted the statistical analysis, and provided a critical review of the manuscript. All authors read and approved the final manuscript.
BMC Nephrology © 2009 BioMed Central, Ltd.
Cite this: Age-related Associations of Hypertension and Diabetes Mellitus with Chronic Kidney Disease - Medscape - Jun 30, 2009.