Bilirubin-induced neurologic dysfunction can occur in term and late-preterm healthy babies, however, can be effectively prevented through rapid reduction of the increased bilirubin load by intensive phototherapy and/or exchange transfusion. However, these interventions leave a very narrow margin of safety for babies who are usually at home and not under direct medical supervision at the natural peak of hyperbilirubinemia (age 3-5 days). To ensure a safe experience with newborn jaundice and to efficiently prevent severe hyperbilirubinemia, such as that of spectrum bilirubin-related toxicities (including Kernicterus), every infant should be systematically screened for the risk of severe hyperbilirubinemia by both clinical and TB/TcB screening for a close follow-up based on the hour-specific bilirubin nomogram for prompt intervention, when necessary.
Pediatr Health. 2009;3(4):369-379. © 2009 Future Medicine Ltd.
Cite this: Screening for Severe Neonatal Hyperbilirubinemia - Medscape - Aug 01, 2009.