An Update on Treatment Strategies for Common Variable Immunodeficiency

Drahomíra Detková, MD, PhD; Teresa Español, MD, PhD


Expert Rev Clin Immunol. 2009;5(4):381-390. 

In This Article

CVID & Pregnancy

Trough IgG levels and absence of acute infections, as stated above, are the best indicators of good replacement therapy in CVID patients, including pregnant women. No specific protocols for pregnant CVID patients have been published; however, doses and their intervals must be adjusted to the individual patient throughout the pregnancy.[101,102] Often, a 2-week interval may be required, mainly in the last trimester of pregnancy when, owing to the active transport of IgG to the fetus,[103,104] the largest doses are required to protect the mother and the fetus.

As pointed out previously, serologic studies in CVID patients are of no use, and the same is true for the usual serologic studies conducted in pregnant CVID women. Infections in all CVID patients, including pregnant women, should be diagnosed by identification of the infectious agent by microbiology and molecular biology techniques.[50]


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