Rosacea and Its Topical Management

M. Gooderham, MSc, MD, FRCPC


Skin Therapy Letter. 2009;14(2) 

In This Article

Sodium Sulfacetamide 10% + Sulfur 5%

Sodium sulfacetamide 10% + sulfur 5% is an older treatment that has gained new popularity. It is used to treat acne, rosacea, and seborrheic dermatitis,[13] and is available in multiple formulations as a lotion, cream, gel, or cleanser.[9,13] The mechanism of action is not well understood, but the sulfacetamide has antibacterial properties, and the sulfur component confers antifungal, antidemodectic, and keratolytic effects.[19] Two studies, one comparing the sodium sulfacetamide-sulfur combination with the vehicle and another comparing it with metronidazole 0.75% gel, showed a significant reduction in both inflammatory lesion counts and erythema scores in papulopustular rosacea.[19,20]


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