Premenstrual Syndrome and Premenstrual Dysphoric Disorder: Quality of Life and Burden of Illness

Andrea J. Rapkin; Sharon A. Winer


Expert Rev Pharmacoeconomics Outcomes Res. 2009;9(2):157-170. 

In This Article

Issues in the Diagnosis and Impact of PMS/PMDD

In addition to the high prevalence of the disorders and the persistence of symptoms across the reproductive years, there are unique factors that contribute to the significant burden of illness associated with the premenstrual disorders and continue to hamper research and development of new therapeutic approaches. The etiology of the disorders is still not known and currently available treatments are not always well tolerated or completely effective. There is a lack of consensus regarding the specific diagnostic criteria and the methods of operationalizing these criteria. The prospective monitoring required for diagnosis hinders epidemiologic research and may not even be performed by treating clinicians. The PMDD diagnostic criteria may be overly narrow so as to exclude many women suffering with PMS. There is also a societal concern that even with strict criteria for diagnosis, the normal phenomenon of the premenstrual molimina will be medicalized as a disorder.


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