Aims
As there is considerable overlap in the fasting serum gastrin concentration found in ZES and more common benign conditions, we aimed to (1) define the clinical causes of hypergastrinaemia; (2) review the association between hypergastrinaemia and two common clinical scenarios, namely acid suppressing medication use and H. pylori infection; (3) define the role of various non-invasive investigations that can be used to establish the cause of hypergastrinaemia and (4) develop an algorithm for the subsequent investigation of patients with elevated (mild-to-modest) fasting serum gastrin concentrations in whom the clinical diagnosis is unclear. We aimed to review predominantly more recent evidence, particularly that published over the last decade.
Aliment Pharmacol Ther. 2009;29(10):1055-1068. © 2009 Blackwell Publishing
Cite this: Review Article: Strategies to Determine Whether Hypergastrinaemia Is Due to Zollinger-Ellison Syndrome Rather Than a More Common Benign Cause - Medscape - May 01, 2009.
