Treatment of Acute Myeloid Leukemia With Hematopoietic Stem Cell Transplantation

Cortney V. Jones; Edward A. Copelan

Disclosures

Future Oncol. 2009;5(4):559-568. 

In This Article

Post-remission Chemotherapy Prior to Allogeneic Transplantation

A large majority of patients who undergo transplantation in first remission receive post-remission 'consolidation' chemotherapy before transplantation. The administration of post-remission chemotherapy to patients who have achieved complete remission and will undergo transplantation has not been shown to improve survival.[58,59,60] While a prolonged time interval between achievement of remission and transplantation may warrant chemotherapy, transplantation can often be expedited by anticipating remission and planning subsequent transplantation in patients whose prognostic factors warrant this approach. Patients who are potential candidates for transplantation should have blood drawn for HLA typing prior to induction therapy. Evaluation for sibling and unrelated matches should proceed as soon as cytogenetic analysis indicates the need for allotransplantation, as patients who do not achieve remission will also be candidates for transplantation. Efficient searches for donors can markedly reduce the interval until transplantation and eliminate or minimize the need for expensive, toxic and unnecessary chemotherapy.

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