Treatment of Acute Myeloid Leukemia With Hematopoietic Stem Cell Transplantation

Cortney V. Jones; Edward A. Copelan

Disclosures

Future Oncol. 2009;5(4):559-568. 

In This Article

Post-remission Chemotherapy

The term 'consolidation therapy' is firmly entrenched, but present understanding of leukemia biology would suggest that merely 'strengthening' of a remission, with persistence of leukemic cells that will eventually cause relapse, is a misguided goal. Post-remission therapy is a more accurate term for treatment with curative intent. Post-remission therapy choices consist of chemotherapy, and autologous or allogeneic transplantation. In nonelderly patients, chemotherapy commonly consists of three to four courses of high-dose cytarabine, which is more effective in prevention of relapse than multiple courses of lower doses of cytarabine combined with anthracyclines.[25,26,27] The beneficial effect of high-dose cytarabine (compared with other forms of chemotherapy) occurs in patients within 'good' or 'intermediate' risk groups classified by cytogenetic analysis ( Table 1 ).

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