Treatment of Acute Myeloid Leukemia With Hematopoietic Stem Cell Transplantation

Cortney V. Jones; Edward A. Copelan

Disclosures

Future Oncol. 2009;5(4):559-568. 

In This Article

Standard Treatment of AML

The goal of initial treatment in AML is to restore normal marrow function by achieving complete remission, defined as recovery of normal peripheral blood counts and the presence of less than 5% blasts (lacking the AML phenotype) in the marrow. Once remission is achieved, post-remission therapy is generally administered. For patients under the age of 60 years, improvements in supportive care have permitted the achievement of complete remission in more than 70% of individuals with AML.[22] Complete remission can be achieved in the vast majority of individuals with standard induction therapy consisting of an anthracycline for 3 days and continuous infusion of cytarabine for 7 days. The addition of other agents has not improved survival, although investigation of better induction regimens is ongoing. Virtually every patient who achieves complete remission following induction therapy, but who does not receive subsequent therapy, will relapse.[23,24] Clearly, induction chemotherapy alone does not eliminate leukemic stem cells.

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