The objective of this study is to assess whether peritoneal dialysis will have less effect on arterial stiffness, vascular function, myocardial structure and function, oxidative stress and inflammation than hemodialysis. Comparing the effects of renal replacement therapy modalities on surrogate cardiovascular markers over time will provide unique important information to assist in the treatment of patients with ESKD. Data from this trial may also lead to a larger scale study assessing the effect of dialysis modality on major cardiovascular endpoints.
Lisa Anderson, Marianne Smith and Colleen Morgan are trial coordinators. Matthew Fassett is constructing the database.Funding information
The Clifford Craig Medical Research Trust including the North West Committee is the major funder of the study. Baxter Healthcare is also funding this study through PD College and CEC grants.
Robert G. Fassett, Renal Research, Royal Brisbane and Women's Hospital, Brisbane, Queensland, 4029, Australia; Email: firstname.lastname@example.org
Baxter Healthcare, although providing a proportion of funding for the study through a competitive grant process, has no influence on the outcome. Although Baxter Healthcare is a provider of peritoneal dialysis therapy it is not the sole provider to the Hospitals included in this study. The outcome of the study will not impact on the balance of product use after completion of the study. However, the study outcome may influence the distribution of the use of peritoneal dialysis compared with hemodialysis in the first twelve months of therapy. This could result in an increased or decreased use of either dialysis therapy or in fact no alteration.
BMC Nephrology © 2009 BioMed Central, Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this: Comparison of Markers of Oxidative Stress, Inflammation and Arterial Stiffness Between Incident Hemodialysis and Peritoneal Dialysis Patients – An Observational Study - Medscape - Mar 12, 2009.