Levetiracetam for Managing Neurologic and Psychiatric Disorders

Muhammad U. Farooq; Archit Bhatt; Arshad Majid; Rishi Gupta; Atul Khasnis; Mounzer Y. Kassab

Disclosures

Am J Health Syst Pharm. 2009;66(6):541-561. 

In This Article

Overdosage

Overdose of levetiracetam has been reported.[108] The highest known dosage of levetiracetam reported in the clinical development program was 6000 mg/day. Other than drowsiness, there were no adverse events in the few known cases of overdose in clinical trials. Cases of somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma were observed with levetiracetam overdoses in postmarketing use. There is no specific antidote for the overdose; general measures, such as emesis, gastric lavage, and supportive care, are advised. Standard hemodialysis procedures result in significant clearance of levetiracetam (approximately 50% in four hours) and should be considered in cases of overdose.

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