Prognosis for PABC is unclear. Studies conducted at Memorial Sloan-Kettering in New York, NY, Mount Sinai School of Medicine in New York, and the Auckland Breast Cancer Study group in New Zealand have shown that stage-matched control groups of pregnant women to nonpregnant women had similar survival rates, but pregnant women often are diagnosed at later stages (Keleher et al., 2002). Larger studies in France and California found that pregnancy had a negative influence on outcomes, regardless of stage at diagnosis (MacReady, 2007). Researchers in both studies believed that circulating hormones in pregnancy and higher rates of the BRCA1 and BRCA2 genetic mutations in younger patients caused significantly poorer outcomes (Keleher et al.). The French study also found that conventional chemotherapy was less effective in patients with PABC, possibly because of tumor biology; additional studies are needed to verify the relationship (Keleher et al.).
Clin J Oncol Nurs. 2009;13(1):25-27. © 2009 Oncology Nursing Society
Cite this: Pregnancy-Associated Breast Cancer - Medscape - Feb 01, 2009.