Pregnancy-Associated Breast Cancer

Kathleen Logue, RNC-OB, BSN


Clin J Oncol Nurs. 2009;13(1):25-27. 

In This Article

Follow-Up of the Child

A case-control study was conducted at the University of Texas M.D. Anderson Cancer Center to evaluate long-term effects on children exposed to chemotherapy in utero (Hahn et al., 2006). The study evaluated children aged two months to 13 years who were exposed to systemic chemotherapy for breast cancer during the second or third trimester of pregnancy. Of the 40 children who met the criteria, no increase in health or mental deficits were found versus control (Hahn et al.). A larger study of 84 children (median age = 18.7 years) born to women with hematologic cancer who underwent chemotherapy during their pregnancy looked at school records, physical and neurologic examinations, cardiac function, psychological evaluations, and bone marrow for chromosomal abnormalities. No abnormalities were found in physical growth or development; neurologic and psychological findings were normal and no cardiac issues were noted (Gwyn, 2005). Additional follow-up is needed to determine the lifelong effects (e.g., fertility, cardiac issues) in adulthood for the children (Hahn et al.).


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.