Atypical Antipsychotic Drugs and Diabetes Mellitus in the US Food and Drug Administration Adverse Event Database: A Systematic Bayesian Signal Detection Analysis

Ross A. Baker; Andrei Pikalov; Quynh-Van Tran; Tatyana Kremenets; Ramin B. Arani; P. Murali Doraiswamy


Psychopharmacol Bull. 2009;42(1):1-21. 

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This database analysis suggests a low association with DRAEs for aripiprazole, haloperidol and ziprasidone, and more frequent associations with DRAEs for olanzapine, clozapine, quetiapine and risperidone. However, as spontaneous reporting of AEs cannot determine causality or definitely determine the relative risk with each agent, the results must be interpreted with caution. Nevertheless, these results are indicative of differential effects of atypical antipsychotics in their propensity to cause DRAEs, are consistent with previously published epidemiological studies and reinforce guidance on the need for metabolic monitoring in patients taking antipsychotic drugs.