Overview of New Therapeutic Developments for Acne

Anja Thielitz; Harald Gollnick

Disclosures

April 13, 2009

In This Article

Other Topical Treatments

Some other new topical compounds were evaluated recently in small clinical trials for their efficacy in acne. A novel lotion containing triethyl citrate and ethyl linoleate was compared with its vehicle in a double-blind, placebo-controlled, randomized study during a 12-week treatment.[48] In total, 40 patients were recruited into the study, of whom 33 completed the study. Active treatment was statistically superior to placebo in reduction of Leeds grading and inflammatory, noninflammatory and total lesion counts. Sebum casual level measured by the sebutape method was significantly reduced in the actively treated group only.

Furthermore, a phytosphingosine product was reported recently to have antimicrobial and anti-inflammatory effects in acne.[49] In addition, picolinic acid, a novel zinc-finger therapy, was reported to be effective in the treatment of mild-to-moderate acne vulgaris in 20 subjects receiving 10% picolinic acid gel twice daily to the face over 12 weeks, of which 15 patients completed the 12-week open-label study.[50] A reduction of 58.2% (p < 0.001) in mean total lesion count, 55.5% (p < 0.001) in mean inflammatory lesion count and 59.7% (p < 0.005) in noninflammatory lesion count was seen in this population. No serious adverse events or clinically significant changes in laboratory values were noted.

The future role of these products in acne therapy will have to be confirmed in well-designed clinical trials involving larger patient populations.

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