Substances or strategies on the cusp of emerging as potential acne treatments are dietary interventions,[84,85,86] insulin sensitizers, anti-inflammatory agents (e.g., leukotriene antagonists[88,89]), P. acnes vaccinations[90,91] and ectopeptidase inhibitors.
Although the effect of strict low-glycemic index diets in acne has been shown in clinical trials, it is questionable whether this will be translatable to everyday practice, because patient education and strict compliance is mandatory. The role of milk in the pathogenesis of acne and the analysis of milk ingredients potentially aggravating acne will be an issue addressed in the next few years.
P. acnes vaccinations mainly address P. acnes-related inflammatory events, as shown in animal experiments and, therefore, must confirm their efficacy in the complex human multifactorial acne pathogenesis. If ectopeptidase inhibitors prove their broad anti-acne in vitro efficacy in humans, they might become a completely new substance group for acne treatment within the next 5-10 years.
Harald Gollnick, University Clinic of Dermatology and Venereology, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany; E-mail: firstname.lastname@example.org
© 2009 Expert Reviews Ltd.
Cite this: Overview of New Therapeutic Developments for Acne - Medscape - Apr 13, 2009.