Overview of New Therapeutic Developments for Acne

Anja Thielitz; Harald Gollnick

Disclosures

April 13, 2009

In This Article

Five-year View

Substances or strategies on the cusp of emerging as potential acne treatments are dietary interventions,[84,85,86] insulin sensitizers,[87] anti-inflammatory agents (e.g., leukotriene antagonists[88,89]), P. acnes vaccinations[90,91] and ectopeptidase inhibitors.[92]

Although the effect of strict low-glycemic index diets in acne has been shown in clinical trials, it is questionable whether this will be translatable to everyday practice, because patient education and strict compliance is mandatory. The role of milk in the pathogenesis of acne and the analysis of milk ingredients potentially aggravating acne will be an issue addressed in the next few years.

P. acnes vaccinations mainly address P. acnes-related inflammatory events, as shown in animal experiments and, therefore, must confirm their efficacy in the complex human multifactorial acne pathogenesis. If ectopeptidase inhibitors prove their broad anti-acne in vitro efficacy in humans, they might become a completely new substance group for acne treatment within the next 5-10 years.

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