Gene-Expression Signatures of Nasal Polyps Associated With Chronic Rhinosinusitis and Aspirin-Sensitive Asthma

Michael Platt; Ralph Metson; Konstantina Stankovic


Curr Opin Allergy Clin Immunol. 2009;9(1):23-28. 

In This Article


Gene-expression profiling has revolutionized the field of genetic analysis by defining expression signatures that enable identification of new disease subtypes, prediction of clinical outcomes, and discovery of novel therapeutic targets. The ability to interpret the large amount of data generated, and to determine the meaning of the individual genes within these signatures remains a challenge. Nonetheless, several genes with altered expression in nasal polyps have been proposed as putative targets for novel therapies for CRS and ASA. Integrated analysis of gene expression signatures and other genome-scale data sets, combined with more traditional single gene/protein approaches, has a potential to substantially advance the current understanding and treatment of CRS and ASA.


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