Gene-Expression Signatures of Nasal Polyps Associated With Chronic Rhinosinusitis and Aspirin-Sensitive Asthma

Michael Platt; Ralph Metson; Konstantina Stankovic


Curr Opin Allergy Clin Immunol. 2009;9(1):23-28. 

In This Article

Complementary Methodologies for Study of Nasal Polyps

This review focuses on insights gained about nasal polyps in patients with CRS and ASA while using a specific technology, high throughput gene-expression profiling. This technology complements other studies that use different techniques to explore nasal polyps. These complementary techniques include targeted explorations of specific genes such as those encoding cytokines[40•] and markers of epithelial inflammation,[52] genes involved in innate immunity,[53] cultures of sinonasal epithelium,[53] characterization of polymorphisms in specific genes,[54] or eventually the entire genome to uncover genetic determinants that confer susceptibility to CRS and ASA.


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