Gene-Expression Signatures of Nasal Polyps Associated With Chronic Rhinosinusitis and Aspirin-Sensitive Asthma

Michael Platt; Ralph Metson; Konstantina Stankovic

Curr Opin Allergy Clin Immunol. 2009;9(1):23-28.

Complementary Methodologies for Study of Nasal Polyps

This review focuses on insights gained about nasal polyps in patients with CRS and ASA while using a specific technology, high throughput gene-expression profiling. This technology complements other studies that use different techniques to explore nasal polyps. These complementary techniques include targeted explorations of specific genes such as those encoding cytokines^[40•] and markers of epithelial inflammation,^[52] genes involved in innate immunity,^[53] cultures of sinonasal epithelium,^[53] characterization of polymorphisms in specific genes,^[54] or eventually the entire genome to uncover genetic determinants that confer susceptibility to CRS and ASA.

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Cite this: Gene-Expression Signatures of Nasal Polyps Associated With Chronic Rhinosinusitis and Aspirin-Sensitive Asthma - Medscape - Feb 01, 2009.

Abstract and Introduction
Gene-expression Profiling in Nasal Polyps
Complementary Methodologies for Study of Nasal Polyps
Conclusion
References

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