Emergency Treatment of Severely Burned Pediatric Patients: Current Therapeutic Strategies

Gerd G. Gauglitz; David N. Herndon; Marc G. Jeschke

Disclosures

Pediatr Health. 2008;2(6):761-775. 

In This Article

Long-term Responses

Despite adequate and rapid treatment immediately, postburn injury is associated with long-term consequences. Recent studies demonstrate that inflammation, hypermetabolism, catecholamines and cortisol are increased for up to 3 years postburn [Jeschke MG et al., Unpublished Data]. These data indicate the local and systemic effects of a burn are not limited to the 95% healed stage. A burn continues to plague and impair patients over a prolonged time. The Glue grant group investigated in a recent study the persistence of genomic changes after burn and found that the genome of white blood cells is altered for up 12 months postburn, indicating the profound changes with a burn injury.[133,134] We therefore initiated several studies to determine whether the long-term effects can be alleviated.[17,76,93,100,107] We found that administration of anabolic agents, such as oxandrolone, growth hormone or propranolol, can improve long-term outcomes. Furthermore, in an unpublished study we found that exercise can tremendously improve strength and rehabilitation of severely burned patients. In summary, a burn is not limited to the acute phase. It is a process that continues over a long time and requires a patient-specific treatment plan in order to improve patient outcome.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....