Levothyroxine Use in Infants and Children with Congenital or Acquired Hypothyroidism

Contributing Editor: Marcia L. Buck, Pharm.D.; Editorial Board: Kristi N. Hofer, Pharm.D.; Michelle W. McCarthy, Pharm.D.


Pediatr Pharm. 2008;14(10) 

In This Article


Replacement of endogenous L-thyroxine (T4) with synthetic levothyroxine has had a significant impact on the long-term effects of both congenital and acquired hypothyroidism in pediatric patients.[1] While the use of levothyroxine in chronic hypothyroid states is well established, new research also suggests a potential benefit of thyroid replacement in the early management of autoimmune thyroiditis and in transient hypothyroid states such as prematurity. This issue of Pediatric Pharmacotherapy will provide an overview of the use of levothyroxine in infants and children with hypothyroidism, as well as a brief review of the drug's pharmacokinetics, drug interactions, adverse effects, and dosing recommendations.


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