Adenosine for the Management of Neonatal and Pediatric Supraventricular Tachycardia

Contributing Editor: Marcia L. Buck, Pharm.D.; Editorial Board: Kristi N. Hofer, Pharm.D.; Michelle W. McCarthy, Pharm.D.

Disclosures

Pediatr Pharm. 2008;14(8) 

In This Article

Pharmacokinetics

Following an intravenous (IV) dose, adenosine is rapidly taken up by erythrocytes and vascular endothelial cells. Intracellular adenosine is metabolized to adenosine monophosphate (AMP) by phosphorylation via adenosine kinase and to inosine by deamination via adenosine deaminase. The resulting AMP formed by phosphorylation is incorporated into the body's high-energy pool. The elimination half-life of adenosine is less than 10 seconds.[3,4]

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