Selective Hypothermia in the Management of Traumatic Brain Injury

Eisha Christian, B.A.; Gabriel Zada, M.D.; Gene Sung, M.D.; Steven L. Giannotta, M.D.


Neurosurg Focus. 2008;25(4):E9 

In This Article


Selective methods of cerebral hypothermia remain a viable option for neuroprotective therapy in patients that have sustained TBI. To date, surface cooling methods and intranasal cooling systems are the only types of selective hypothermia that have been tested in humans following TBI, whereas endovascular, extraluminal, and epidural cooling methods have been tested only in animal models and patients with stroke. Studies in which authors compare and possibly combine several methods may be indicated in the future. For now, the least invasive and most selective methods of hypothermia hold the greatest promise in becoming practical measures for providing neuroprotection following TBI. Further prospective research is clearly indicated to delineate the risks and benefits associated with these new therapies.


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