Clinical Evaluation of Perspiration Reducing Effects of a Kampo Formula, Shigyaku-san, on Palmoplantar Hidrosis

Fumino Ninomiya

Disclosures

Evid Based Complement Alternat Med. 2008;5(2):199-203. 

In This Article

Abstract and Introduction

Abstract

Palmoplantar hidrosis is common in patients who are susceptible to strains on the autonomic nervous system, and stress and mental strain have been proven to produce sweating in this population. Shigyaku-san (Sini san, TJ-35: Tsumura & Co.) is effective for relieving stagnation of 'liver Qi and vital energy' in traditional Chinese medicine theory; this brings about improvement of palmoplantar hidrosis. The effect of Shigyaku-san on 40 patients was evaluated based on changes in palmoplantar sweat volume and skin temperature before and after stress loading. We also measured changes in the palmoplantar sweat volume and skin temperature due to stress load in 35 healthy controls who did not receive Shigyaku-san. Before treatment, the pre-stress sweat volume in patients was larger than that in healthy controls, however, after Shigyaku-san treatment, their pre-stress sweat volume decreased. With stress, the sweat volume increased in both patients and controls, but the net increase in the patients was larger than that in healthy controls. After Shigyaku-san treatment, the net increase of sweat volume due to stress was smaller than that of pretreatment, however, it did not show a significant difference with that of healthy controls. The palmoplantar skin temperature of the patients before treatment was lower than that of healthy controls. Palmoplantar skin temperature rose with stress loading in healthy controls, but decreased in pretreatment patients. Shigyaku-san treatment reduced the palmoplantar perspiration in palmoplantar hidrosis patients at rest and under stress. Furthermore, it also improved other serious complications, especially coldness of the extremities.

Introduction

Palmoplantar hidrosis is common in patients who are susceptible to strain on the autonomic nervous system, and stress and mental strain have been proven to produce sweating in this population. It is known that physiological sweating due to exercise is mediated by stimulation of the sudorific center in the hypothalamus, while sweating due to stress is mediated by stimulation of the sudorific center in the frontal area, which causes an increase in autonomic nerve strain that leads to palmoplantar sweating.[1,2]

Patients with palmoplantar hidrosis often present with lower body coldness, purulent blisters, erythema, facial flushing, atopic dermatitis, constipation and menstrual disorders.

In the present study, I evaluated the effects of Shigyaku-san (Sini san, TJ-35: Tsumura & Co., Tokyo, Japan)[3] on sweat volume and skin temperature in patients with palmoplantar hidrosis with such troublesome complications. Shigyaku-san seems to be effective for relieving stagnation of liver Qi and vital energy in traditional Chinese medicine (TCM) theory, leading to an improvement in palmoplantar hidrosis and its accompanying symptoms.

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