Autism Spectrum Disorder-associated Biomarkers for Case Evaluation and Management by Clinical Geneticists

David A. Geier; Mark R. Geier

Disclosures

Expert Rev Mol Diagn. 2008;8(6):671-674. 

In This Article

Oxidative Stress/inflammation Biomarkers

Reactive oxygen species are a natural by-product of the normal metabolism of oxygen, which results in unstable atoms that cause disruption to other molecules and subsequent damage to cells. Recent studies revealed that biomarkers of oxidative stress were increased in ASDs.[23,24,25,28,29,30,31,32] Furthermore, investigators observed a significant correlation between decreased antioxidant proteins and the loss of previously acquired skills.[29] Investigators also found a correlation between Childhood Autism Rating Scale scores and advanced glycation end products known to promote neuro-inflammation, oxidative stress and neuronal degeneration.[32] In addition, investigators observed neuroglial activation and evidence of neuro-inflammation in ASDs.[33]

Oxidative stress/inflammation biomarkers from LabCorp include an oxidative stress panel (Test#853047) and neopterin (Test#140335) testing. Aldactone® (spironolactone), a drug with demonstrated anti-inflammatory effects, was suggested as a therapeutic intervention for increased oxidative stress/inflammation in ASDs.[34]

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