The Epidemiology of Nonalcoholic Fatty Liver Disease: A Global Perspective

Mariana Lazo, M.D., M.Sc.; Jeanne M. Clark, M.D., M.P.H.


Semin Liver Dis. 2008;28(4):339-350. 

In This Article

Incidence of NAFLD

In contrast to the vast epidemiological data on the prevalence of NAFLD, there are very little published data on the incidence of this disease, both in the general population and among high-risk groups. Hamaguchi et al studied the incidence of US-defined NAFLD in 3,147 healthy Japanese men (mean age 48.3 and mean BMI 22.6 kg/m2); after a mean follow-up of 414 days (SD = 128) they observed 308 (9.8%) new cases of NAFLD.[37] In a more recent study, Susuki et al prospectively investigated the incidence of elevated liver enzymes (AST or ALT) among 529 employees in a Japanese government office. During the 5-year follow-up, 71 (13%) developed hypertransaminasemia.[48]


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