Carlo Catassi; Alessio Fasano


Curr Opin Gastroenterol. 2008;24(6):687-691. 

In This Article


Celiac disease is a unique model of autoimmunity in which some of the genes involved, the target autoantigen, and, most importantly, the environmental trigger, are all known. Therefore, celiac disease represents a superb model to study the genetic, immunological, epidemiological, and clinical aspects of multifactorial diseases. Given the undisputable role of gluten in inducing the autoimmune intestinal insult typical of celiac disease, the GFD is considered the only effective treatment for individuals with celiac disease. However, the implementation of a GFD is challenging and most of the time suboptimal. A better understanding of the complexity of the genetic/environmental interaction responsible for celiac disease development opens the way to explore alternative therapeutic strategies. It is possible that reducing the 'strength' or the access of the environmental component will prevent disease recurrence, particularly in those patients with a lower genetic load of predisposing genes.


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