The Myth of Equipoise in Phase 1 Clinical Trials

Adil E. Shamoo, PhD


Medscape J Med. 2008;10(11):254 

In This Article


Phase 1 clinical research trials using healthy volunteers are conducted for the sole purpose of serving the public good (a utilitarian concept). The literature on equipoise analysis does not exclude phase 1 trials with controls or healthy volunteers from the claim of being in "equipoise." The continued perpetuation of this ethically and scientifically invalid concept undermines the ethics of research with human subjects.



Reader Comments on: The Myth of Equipoise in Phase 1 Clinical Trials
See reader comments on this article and provide your own.

Readers are encouraged to respond to the author at or to Peter Yellowlees, MD, Deputy Editor of The Medscape Journal of Medicine, for the editor's eyes only or for possible publication as an actual Letter in the Medscape Journal via email:


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.