Clinical Evidence for Rebound Hypercoagulability After Discontinuing Oral Anticoagulants for Venous Thromboembolism

David Keith Cundiff, MD

Disclosures

Medscape J Med. 2008;10(11):258 

In This Article

Conclusion

Increasing the duration of OAC treatment for VTE does not significantly reduce the overall adverse events. Rebound hypercoagulability accounts for about 2% of patients having recurrent VTE in the first 2 months after discontinuing OACs. RCTs evaluating the efficacy of OACs in VTE should include data for at least 2 months following OAC treatment. Trials of antithrombotic drug treatment for other indications should include data for appropriate time intervals after discontinuing the drugs.

Comments

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