Darrell Hulisz, RPh, PharmD; Melissa Lagzdins, RPh, PharmD


US Pharmacist. 2008;33(9):HS11-HS20. 

In This Article


The effects of caffeine on blood pressure control are not well defined. A meta-analysis of randomized controlled trials analyzing the effect of either coffee or caffeine alone on blood pressure levels was recently published.[23] A total of 16 studies with randomized, controlled designs were selected for review, representing 1,010 subjects. An increase of 2.04 mmHg in systolic blood pressure and of 0.73 mmHg in diastolic blood pressure was found after pooling these trials. When the coffee and caffeine trials were analyzed separately, the blood pressure elevations induced were larger with caffeine (410 mg/day) than with coffee (725 mL/day). The effects of coffee and caffeine on heart rate were not significant.


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