This is the Medscape Medical Minute. I'm Dr. George Lundberg.
Tobacco addiction remains the top killer of humans in the developed world. But most smokers want to quit. How can we help them? Ten investigators from Montreal performed a meta-analysis of 69 published double-blind, randomized, placebo-controlled trials of 7 approved pharmacotherapies for smoking cessation. Published in the CMAJ in 2008, these studies, found in 4 large databases, included biochemically validated measures of abstinence at 6 and 12 months. Odds ratios of efficacy compared with placebo ranged from the top of 2.41 for varenicline to the low of 1.71 for nicotine gum. Take your pick. All 7 help to promote abstinence from smoking tobacco.
This article is selected from Medscape Best Evidence. I'm Dr George Lundberg.
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Cite this: Seven Pharmacotherapies Do Promote Smoking Abstinence at 6 and 12 Months - Medscape - Oct 30, 2008.