Antioxidants Used in Skin Care Formulations

I. Bogdan Allemann, MD; L. Baumann, MD


Skin Therapy Letter. 2008;13(7):5-8. 

In This Article


The synthetic analog of coenzyme Q10 is called idebenone, which has been demonstrated to be stronger than CoQ10 and other well known antioxidants.[20] In humans, a study with a topical skin care formulation containing idebenone showed positive effects on photodamaged skin (i.e., reduction in skin roughness/dryness, reduction in fine lines/wrinkles).[21] However, the effects on wrinkles were most likely due to hydration or skin irritation. There is 1 report of contact dermatitis attributed to idebenone 0.5% in a cream.[22] However, the authors have seen many patients who developed contact dermatitis from skin care products containing idebenone.


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