Antioxidants Used in Skin Care Formulations

I. Bogdan Allemann, MD; L. Baumann, MD

Disclosures

Skin Therapy Letter. 2008;13(7):5-8. 

In This Article

Vitamin E

Vitamin E (tocopherol) is a lipid-soluble antioxidant that is present in the skin and found in various foods, such as vegetables, seeds, and meat.[8] There are 8 active isoforms that are grouped into tocopherols and tocotrienols. Of the 4 tocopherols (α-, β-, γ- and δ-), á-tocopherol (AT) has the highest activity. In animals, a topical application of á-tocopherol has been shown to exert photoprotective effects by reducing the number of sunburn cells,[9] reducing ultraviolet B (UVB)-induced damage,10 and inhibiting photocarcinogenesis.[11] In humans, tocopherol 5%-8% cream that was applied to the face improved signs of photoaging when compared with placebo.[12] Furthermore, application of vitamin E (5%) to human skin under light-tight occlusion 24 hours before UV treatment was shown to inhibit human macrophage metalloelastase, a member of the matrix metalloproteinase family involved in the degradation of elastin.[13]

Newer studies suggest that the combined application of various antioxidants can increase their potency when compared with 1 antioxidant alone, and consequently can provide superior photoprotection, as has been shown for the combination of vitamins E and C.[14] Topical application of vitamin E has been linked with various cutaneous side-effects, including contact dermatitis.[15,16,17]

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....