Conclusion
The use of topically applied antioxidants seems promising; however, there is a paucity of controlled clinical trials in humans examining the role of antioxidants in preventing or decelerating skin aging. Thus, further experimental data needs to be generated. Current research suggests that combinations of different antioxidants seem to have synergistic effects and, thus, better efficacy, when compared with 1 antioxidant used alone.[61,62] Also, some data suggest that a cumulative or additive benefit can be derived from using oral and topical antioxidant products in combination.[63,64] In spite of the lack of data, millions of dollars are spent annually on these products worldwide. At this point, it is important to understand that these agents are harmless when applied topically, but the exact efficacy of these products is currently unknown.
Skin Therapy Letter. 2008;13(7):5-8. © 2008 SkinCareGuide.com
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