Hypothalamic Regulation of Appetite

Katherine A. Simpson; Niamh M. Martin; Steve R. Bloom


Expert Rev Endocrinol Metab. 2008;3(5):577-592. 

In This Article

Clinical Therapeutic Applications

In conclusion, the hypothalamic control of appetite is complex and relies not just on signaling pathways within the brain but also peripheral signals acting via the brainstem and reward circuitries. As such, there are multiple potential targets for developing anti-obesity agents.[217] However, due to the complexity of neuronal circuits involved in appetite control, it is unlikely that targeting one specific pathway will result in prolonged and clinically relevant weight loss. Understanding and hence modulating several pathways, including those affecting the brainstem and gut hormone profile, is likely to be a more successful approach and may provide real hope for effective treatments for obese patients.


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