The challenge ahead will be to try and discern how the complex pathways and neuropeptides within the hypothalamus interact to affect appetite. In addition to discovering new peptides that influence food intake, the focus will be on modulating known central pathways using peripherally administered agents. In reality, management of obesity will be like that of hypertension, requiring lifelong multiple agents in order to achieve the weight loss required. Delivery of drugs acting centrally will be vital and will need to overcome barriers, such as the short half-life of peptides, ability to cross the blood-brain barrier, side effects and safety profile.
We are grateful to Chris McCullough for his assistance with the illustrations that were produced.Reprint Address
Steve R. Bloom, Department of Investigative Medicine, Imperial College, London W12 ONN, UK. E-Mail: firstname.lastname@example.org
Expert Rev Endocrinol Metab. 2008;3(5):577-592. © 2008 Future Drugs Ltd.
Cite this: Hypothalamic Regulation of Appetite - Medscape - Sep 01, 2008.