Miscarriage and Its Associations

Stephen Brown, M.D.


Semin Reprod Med. 2008;26(5):391-400. 

In This Article

Reproductive History

From the patient's perspective, one question that arises repeatedly is, "Now that I have had a miscarriage, what are the chances that my next pregnancy will end in miscarriage?" Stated differently, what impact does reproductive history have on probability of miscarriage? Several studies have shown that the chance of a subsequent miscarriage increases as the number of previous losses increases (summarized in Table 2 ). Although these data do not offer any insight into cause, a history of miscarriage is clearly associated with an increased risk. Note that the most recent of the studies[14] indicates that primagravid women have a miscarriage rate of only 5% and that a history of only one loss confers a very substantial increase in risk. Given the fact that most aneuploidy is age-related and largely nonrecurrent, and given the fact that early miscarriage is much more likely to be due to aneuploidy, it is reasonable to assume that late losses in younger women predict a poorer reproductive future than do early losses.


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