Miscarriage and Its Associations

Stephen Brown, M.D.


Semin Reprod Med. 2008;26(5):391-400. 

In This Article

Paternal Age

Although the effects of maternal age and trisomy have received a great deal of attention, there are good data to show that paternal age has a significant impact on the chance of miscarriage, even when maternal age is controlled for. For instance, one large case-control study showed that the odds ratio for pregnancy loss was 1.6 when the father was greater than 40,[12] and a second found a similar increased risk with fathers older than 35 years.[13] Although these effects are too modest to have much impact on clinical practice, they may be of psychological benefit to older couples experiencing pregnancy loss.


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