Miscarriage and Its Associations

Stephen Brown, M.D.

Disclosures

Semin Reprod Med. 2008;26(5):391-400. 

In This Article

X-Chromosome Inactivation Skewing

In females, one of the two X chromosomes is inactivated in early embryonic life, a process that generally occurs randomly. X chromosome inactivation skewing occurs in situations in which there is a cellular survival advantage associated with one of the two Xs remaining active. Structural abnormalities of the X chromosome or the presence of a dominantly acting lethal mutation are examples of when this might occur. A relatively recent development has been the purported association with skewed (or nonrandom) X-chromosome inactivation with miscarriage, although the possible biological basis for such an association has not been clear. Earlier reports seemed to show a strong association,[44,45,46] whereas later reports have not.[47] Overall, it seems that this association is weak at best.

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