Therapy Insight: The Changing Spectrum of Rheumatic Disease in HIV Infection

Rashmi M. Maganti; John D. Reveille; Frances M. Williams


Nat Clin Pract Rheumatol. 2008;4(8):428-438. 

In This Article


The impact of the global HIV pandemic continues to grow, and consequently rheumatologists need to be aware of the wide spectrum of rheumatic diseases that occur in HIV-positive individuals. HAART has changed the natural history of HIV infection: this therapy has modified the frequency and presentation of some HIV-related clinical syndromes and has been associated directly (via toxic effects) and indirectly (via immune reconstitution) with the development of new ones. Prudent use of immunosuppressive therapy and constant vigilance for unusual and opportunistic infections are necessary. Rheumatologists need to be aware of these changes to ensure they can provide accurate diagnosis and optimum treatment for this group of patients.

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