Thiazolidinediones and Cardiovascular Disease: Balancing Benefit and Harm

Sonal Singh, MD; Yoon K. Loke, MD


Geriatrics and Aging. 2008;11(3):179-183. 

In This Article


The thiazolidinediones carry significant cardiovascular risks (heart failure, MI) and are associated with negative effects elsewhere in the body (bone fractures). In the absence of any meaningful benefits to patients, thiazolidinediones should be avoided for older adults with diabetes who are at risk of cardiovascular events (heart failure, heart attack). Ongoing and future trials in diabetes should measure patient-oriented outcomes rather than surrogates.


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