Thiazolidinediones and Cardiovascular Disease: Balancing Benefit and Harm

Sonal Singh, MD; Yoon K. Loke, MD

Disclosures

Geriatrics and Aging. 2008;11(3):179-183. 

In This Article

Conclusions

The thiazolidinediones carry significant cardiovascular risks (heart failure, MI) and are associated with negative effects elsewhere in the body (bone fractures). In the absence of any meaningful benefits to patients, thiazolidinediones should be avoided for older adults with diabetes who are at risk of cardiovascular events (heart failure, heart attack). Ongoing and future trials in diabetes should measure patient-oriented outcomes rather than surrogates.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....