Vitamin D in Systemic Lupus Erythematosus

Diane Kamen; Cynthia Aranow

Disclosures

Curr Opin Rheumatol. 2008;20(5):532-537. 

In This Article

Protective Immunity

In addition to its functions in maintaining self-tolerance, vitamin D has an important role in protective immunity. Vitamin D enables the eradication of Mycobacterium tuberculosis by human macrophages through an induction of the innate immune system leading to the production of cathelicidin, an antimicrobial peptide. Macrophages cultured in vitamin D-deficient sera expressed significantly lower amounts of cathelicidin, which could be restored by addition of vitamin D to the culture media.

Vitamin D has also been shown to augment antibody-mediated immunity. 1,25D used as an adjuvant with an Escherichia coli vaccine in cattle resulted in increased serum immunoglobulin G (IgG) and IgG1 antibodies to the E. coli strain. IgG2 antibodies were diminished.[24] Administration of 1,25D inhibited the murine IgG2a response to a pneumococcal capsular polysaccharide in an IL-12-dependent manner without affecting other IgG isotypes.[25]

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