Vitamin D in Systemic Lupus Erythematosus

Diane Kamen; Cynthia Aranow

Disclosures

Curr Opin Rheumatol. 2008;20(5):532-537. 

In This Article

Effects on the 'Interferon Signature' in Systemic Lupus Erythematosus

Studies of peripheral blood gene expression profiles of SLE patients have shown an upregulation of IFNa-inducible genes. This pattern of gene expression, termed the 'interferon signature', occurs in approximately 50% of patients and correlates with disease activity. Plasmacytoid dendritic cells release IFNa after stimulation by nucleic acid containing immune complexes and are the source of the IFN responsible for this signature. SLE plasma is capable of inducing/transferring the IFN signature to normal, nonautoimmune PBMCs. We have also recently shown that vitamin D suppresses the expression of the IFN signature in MDDCs generated from both SLE patients and normal donors which are incubated with plasma from SLE patients (unpublished data).

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