Vitamin D in Systemic Lupus Erythematosus

Diane Kamen; Cynthia Aranow

Disclosures

Curr Opin Rheumatol. 2008;20(5):532-537. 

In This Article

Pluripotent Effects of Vitamin D

Vitamin D exerts its biologic effects through the widely distributed vitamin D receptor (VDR), a member of the steroid super family of receptors. The 1,25D-VDR complex dimerizes with the retinoid X receptor (RXR). This complex (1,25D-VDR-RXR) binds to vitamin D response elements of vitamin D-regulated genes. The potential for vitamin D to act in a local immunological regulatory role is suggested by observations that immune cells including T cells, B cells, macrophages and dendritic cells all express the vitamin D receptor coupled with the findings that both macrophages and mature dendritic cells possess the enzymes necessary to produce the biologically active 1,25D from vitamin D3.

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