Vitamin D in Systemic Lupus Erythematosus

Diane Kamen; Cynthia Aranow


Curr Opin Rheumatol. 2008;20(5):532-537. 

In This Article

Pluripotent Effects of Vitamin D

Vitamin D exerts its biologic effects through the widely distributed vitamin D receptor (VDR), a member of the steroid super family of receptors. The 1,25D-VDR complex dimerizes with the retinoid X receptor (RXR). This complex (1,25D-VDR-RXR) binds to vitamin D response elements of vitamin D-regulated genes. The potential for vitamin D to act in a local immunological regulatory role is suggested by observations that immune cells including T cells, B cells, macrophages and dendritic cells all express the vitamin D receptor coupled with the findings that both macrophages and mature dendritic cells possess the enzymes necessary to produce the biologically active 1,25D from vitamin D3.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: