Vitamin D in Systemic Lupus Erythematosus

Diane Kamen; Cynthia Aranow

Disclosures

Curr Opin Rheumatol. 2008;20(5):532-537. 

In This Article

Conclusion

The physiologic and clinical significance of vitamin D deficiency in SLE is not entirely known. Multiple SLE cohorts have low 25D levels; many extraordinarily low. To date, there are no prospective studies of disease parameters and vitamin D. The full effects of repleting deficient vitamin D levels to 'sufficiency', the 25D level necessary for immunologic homeostasis and what dose of vitamin D this might require are not known. Given its relative safety in conjunction with its beneficial immunomodulatory effects, there is optimism that correcting vitamin D deficiency will lead to better outcomes for patients with SLE.

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