Vitamin D in Systemic Lupus Erythematosus

Diane Kamen; Cynthia Aranow


Curr Opin Rheumatol. 2008;20(5):532-537. 

In This Article


The physiologic and clinical significance of vitamin D deficiency in SLE is not entirely known. Multiple SLE cohorts have low 25D levels; many extraordinarily low. To date, there are no prospective studies of disease parameters and vitamin D. The full effects of repleting deficient vitamin D levels to 'sufficiency', the 25D level necessary for immunologic homeostasis and what dose of vitamin D this might require are not known. Given its relative safety in conjunction with its beneficial immunomodulatory effects, there is optimism that correcting vitamin D deficiency will lead to better outcomes for patients with SLE.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: