Company
|
Drug
|
Web site visited
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Ease of navigation
|
Results
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If limited data on company Web site, findings on www.clinicalstudyresults.org
|
Type of information provided
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# of studies on company Web site or PHRMA Web site
|
# of previously published studies
|
# of previously published negative studies
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# of previously unpublished negative studies
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Abbott |
Depakote (divalproex sodium) |
www.abbott.com |
Link to "Depakote"; link to "Professionals"; link to "Proven Efficacy." No further data. |
No data |
1 unpublished positive study for Depakote ER in acute mania[38]; no data provided. No reference to 2 previously published positive studies in acute mania,[39,40] and a failed maintenance study.[41]
|
Only title of study |
1 |
0 |
0 |
0 |
AstraZeneca |
Seroquel (quetiapine) |
www.astrazeneca.com |
Link to "AstraZeneca-US"; Link to "Products"; Link to "Seroquel"; Link to "Healthcare professionals." No further data. |
4 in acute mania reported, 3 positive have been published,[42,43,44] and 1 negative unpublished study in acute mania;[45] 1 positive published study in acute bipolar depression[46]
|
NA |
Full protocol with detailed summary of results. Mean ± SD length 8.6 ± 1.1 pages (range 7-10) |
6 |
5 |
0 |
1 |
Bristol-Myers Squibb |
Abilify (aripiprazole) |
www.bms.com |
Link to "Clinical trials disclosure"; Link to "Clinical trials registry"; Link to "Therapeutic areas"; Link to "Psychiatric disorders"; |
5 studies in acute mania, bipolar depression, or mania cited by titles and listed as "Recruiting" with no further information; 3 studies cited as "no longer recruiting" and 1 as "completed." No citations provided. |
No titles or data.
No reference to 2 previously published positive studies.[47,48]
|
Titles of studies only |
5 |
2 |
0 |
1 |
Eli Lilly |
Zyprexa (olanzapine) |
www.elililly.com |
Link to "Products"; link to "Lilly clinical trials"; link to "Trials results by product"; link to "Zyprexa" |
6 studies of acute mania, 3 studies of relapse prevention, all positive published studies[49,50,51,52,53,54,55,56,57]
|
NA |
Full protocol with detailed summary of results. Mean ± SD length 15.6 ± 8.0 pages (range 6-28) |
10 |
9 |
1 |
0 |
Eli Lilly |
Symbiax (olanzapine-fluoxetine combination) |
www.elililly.com |
Link to "Products"; link to "Lilly clinical trials"; link to "Trials results by product"; link to "Symbiax" |
1 positive study in acute bipolar depression[58]
|
NA |
Full protocol with detailed summary of results. Length 16 pages |
1 |
1 |
0 |
0 |
GSK |
Lamictal (lamotrigine) |
www.gsk.com |
Link to "Clinical trial register"; link to "Lamotrigine" |
See Table 2 |
NA |
See Table 2 |
9 |
2 |
2 |
5 |
Janssen |
Risperdal (risperidone) |
www.janssen.com |
Link to "Our products"; link to "Risperdal"; link to "Risperdal for bipolar mania" |
No data |
No titles or data. No reference to four previously published positive studies in acute mania,[59,60,61,62] or one previously published negative but underpowered study in acute bipolar depression[63]
|
No titles or data |
0 |
4 |
1 |
0 |
Pfizer |
Geodon (ziprasidone) |
www.pfizer.com |
Link to "Medicines and products"; link to "Geodon"; link to "For healthcare professionals"; link to "Clinical trial data"; link to "Geodon for bipolar mania and mixed episodes" |
One efficacy graph from 1 published study provided[64]
|
2 positive studies in acute mania, 1 published [64] and 1 unpublished. [65] No reference to another positive published acute mania trial[66]
|
Full protocol with detailed summary of results. Mean ± SD length 7.0 ± 2.0 pages (range 5-9) |
2 |
2 |
0 |
0 |
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